This Week At PRICE (July 17th to July 21st)

New Publications In Neighborhood Deprivation and Oxycodone Reward Behaviors


Knee osteoarthritis is a degenerative joint disease of the knee that usually results from the progressive loss of articular cartilage.  An estimated 250 people worldwide suffer from it, with older adults experiencing the greater likelihood of having it. 

The article, ‘Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain’, which has recently been published in Social Science and Medicine, was authored by over 17 researchers, including Roger Fillingmin, Yenisel Cruz-Almeida, Jessica Peterson and Larissa Strath.  Within the study, the relationship between neighborhood deprivation and pain severity knee osteoarthritis was studied as well as how epigenetic age acceleration affects said relationship. 

The results of the study leaned towards the thought that neighborhood deprivation leads to worse knee osteoarthritis pain outcomes, with epigenetic age acceleration acting as the likely vehicle through which it takes place. 

Learn more and read the article here!


For individuals who experience chronic pain, oxycodone and other drugs tend to deliver relief.  It goes without saying however, that risks exists wherein drugs can often become misused. 

Ariana C. Brice-Tutt, who headed the study, worked along PRICE affiliates and Professors, Robert Caudle and John Neubert, as well as other researchers from within the University’s staff and faculty to test the drug reward and misuse potential on rats. 

In the article, ‘An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats’, which has been published in Scientific Reports, it was suggested through rigorous testing that chronic pain does not in fact often reinstate drug seeking behavior. 

Follow the link to learn more about the study here