Current PRICE Studies


Interested in joining the PRICE registry to be informed of studies you may be eligible for?




Understanding Pain and Limitations in Osteoarthritic Disease (UPLOAD) Follow-Up

The purpose of the study is to evaluate changes in pain, functioning, and biological measures reflecting system burden over a four year period in a large group of ethnically diverse older adults with and without knee osteoarthritis. This information will provide an improved understanding of individual differences in osteoarthritis symptoms and may help identify targets for prevention and treatment.


Understanding Pain and Limitations in Osteoarthritic Disease (UPLOAD)-2

This project examines ethnic group differences in clinical symptoms, systemic inflammation, psychosocial functioning and pain-related central nervous system (CNS) structure and function at baseline and over a two-year follow-up period among older adults with knee OA.


Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)-2

Temporomandibular disorders (TMD) and other idiopathic pain conditions (IPCs) affect tens of millions of people in the United States. These conditions often co-occur in the same individual, suggesting that there may be shared risk factors of IPCs. This protocol investigates biopsychosocial risk factors for developing one or more of the following IPCs: TMD, chronic widespread pain, headache, low back pain, or irritable bowel syndrome.


Study of Orofacial Pain and ProPRANOlol (SOPPRANO)        

This project aims to conduct a clinical trial to evaluate the efficacy of the non-selective β-adrenergic antagonist, propranolol, compared to placebo, for treatment of pain in patients with temporomandibular disorder (TMD), and to determine whether propranolol efficacy is influenced by catechol-O-methyltransferase (COMT) genotype. We will enroll 200 TMD patients across two sites in a 10-week treatment trial. The primary endpoint will be a weekly mean pain index from a Daily Symptom Diary.



This study examines cortico-striatal circuits recently described in predicting the transition from acute to chronic pain, in predicting age-related versus pain-related changes to pain modulation which is thought to be a risk factor for clinical pain development.



This project conducts a preliminary ancillary study (ENRGISE-A), capitalizing on and extending the ENRGISE (ENabling Reduction of low-Grade Inflammation in Seniors) parent study to generate preliminary evidence of the influence of systemic low grade inflammatory processes on age-associated clinical and experimental pain, cognitive deficits, brain dysfunction and neuroinflammatory processes.



The purpose of the study is to investigate non-invasive strategies that may optimize the neurobiological environment and improve learning and memory in the treatment of chronic knee osteoarthritis pain.